Viktor Pastukh, Ph.D.
Instructor
USA Department of Pharmacology
Ph.D.: Institute of Biochemistry, Ukrainian Academy of Sciences, Kiev, Ukraine
Post-doctoral: University of South Alabama, Mobile, AL
Phone: (251) 460-6786
vpastukh@southalabama.edu
Research Interests
- Role of mitochondrial DNA damage in endothelial cell apoptosis caused by oxidative stress, role of vascular endothelial growth factor (VEGF) in lung vessels remodeling;
- Apoptosis in lung cells;
- Role glucose, fatty acid and insulin in mitochondrial DNA damage in cardiomyocytes caused by oxidative stress;
- Insulin-linked regulators of the MPT pore;
- Role of the T-type Ca2+ channel in osmotic preconditioning;
- Cell signaling systems (Ca2+, PI 3-kinase/Akt pathway, protein kinase C) after hypoxia and in osmotic preconditioning;
- Apoptosis in cardiomyocytes;
- Role of angiotensin II in cardiomyopathy;
- Cell signaling systems (Ca2+, cyclic nucleotides, inositol system, protein kinases) after irradiation in low doses;
- Role of 5-lipoxygenase activity in lymphocytes of rat spleen after irradiation.
Representative Publications
- Schaffer SW, Pastukh V, Solodushko V, Kramer J, Azuma J. (2002) Effect of ischemia, calcium depletion and repletion, acidosis and hypoxia on cellular taurine content. Amino Acids. 23 (4): 395-400.
- Schaffer S, Solodushko V, Pastukh V, Ricci C, Azuma J. (2003) Possible Cause of Taurine-deficient Cardiomyopathy: Potentiation of Angiotensin II Action. J. Cardiovascular Pharmacol. 41(5):751-759.
- Grishko V, Pastukh V, Solodushko V, Gillespie M, Azuma J, Schaffer S. (2003) Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damage. Ams J Physiol Heart Circ Physiol. 285(6):H2364-72.
- Pastukh V, Ricci C, Solodushko V, Mozaffari M and Schaffer SW. (2005) Contribution of the PI 3-kinase/Akt survival pathway to osmotic preconditioning. Mol Cell Biochem 269: 59-67.
- Pastukh V, Wu S, Ricci C, Mozaffari M and Schaffer SW. (2005) Reversal of hyperglycemic preconditioning by angiotensin II: Role of calcium transport. Am J Physiol Heart Circ Physiol 288:H1965-H1975
- Ricci C, Pastukh V, Schaffer SW (2005) Involvement of the mitochondrial permeability transition in angiotensin II-mediated apoptosis. Exp Clin Cardiol, 10(3):160-164
- Ricci C, Pastukh V, Leonard J, Wilson G, Schaffer D, Schaffer SW (2008) Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis Am J Physiol Cell Physiol.294(2):C413-22.
- Pastukh V, Ruchko M, Gorodnya O, Wilson GL, Gillespie MN (2007) Sequence-specific oxidative base modifications in hypoxia-inducible genes Free Radic Biol Med. 43(12):1616-26.
- Ruchko MV, Gorodnya OM, Pastukh VM, Swiger BM, Middleton NS, Wilson GL, Gillespie MN (2009) Hypoxia-induced oxidative base modifications in the VEGF hypoxic response element re associated with transcriptionally active nucleosomes Free Radic Biol Med. 46(3):352-59